Clinical studies on skin health indicate potential effects on melanin index and skin brightness with sustained use [13] [14]
doi.org/10.1038/nature03000 Regulatory Status FDA, WADA anti-doping, and compounding status provided for research context
The analytical technique in that study (liquid chromatographyisotopic dilution mass spectrometry) more closely resembles the LCMS/MS assay we used than does the HPLC technique used by Borgstrm and colleagues in their 1986 study [4]
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Due to limitations in our ability to pinpoint the subcellular localization of these enzymes in different clinical conditions, it would be only speculative to posit specific intracellular mechanisms related to the effects we report